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KMID : 0356920080550060723
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Korean Journal of Anesthesiology
2008 Volume.55 No. 6 p.723 ~ p.730
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The comparison of the relaxant effects of propofol, thiopental, ketamine, and etomidate on isolated rat uterine smooth muscle
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Eun Sam-Sung
An Tae-Hun
Jung Jong-Dal
Lim Kyung-Joon
Yu Byung-Sik
So Keum-Young
Song Chang-Hoon
Kim Sang-Hun
Jung Ki-Tae
Lee Hyun-Young
Shi Honglin
Lin Ji
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Abstract
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Background: Intravenous hypnotics are used in pregnancy, labor and delivery. The aim of the present study was to investigate and compare the relaxant effects of propofol, thiopental, ketamine, and etomidate on isolated rat uterine smooth muscles.
Methods: Uterine smooth muscle preparations were obtained from non-pregnant female rats. The uterus of the rat was dissected and cut into 10 mm strips. The muscle strips were bathed in Krebs solution. After spontaneous uterine contractile activity had been accomplished, propofol, ketamine, thiopental, and etomidate in various concentrations were added cumulatively to the baths and resting tension, active tension, and frequency of contration were recorded at each concentration of agents. EC5, EC25, EC50, EC75, and EC95 of each drug on active tension and frequency of contraction were calculated using a probit model.
Results: Propofol, thiopental, and etomidate reduced uterine contractions in a concentration-dependent manner. Ketamine concentrations of 10?7 to 10?5 M augmented uterine contractions but ketamine concentrations of 10?4 to 10?3 M attenuated uterine contractions. The EC50’s of propofol, thiopental, ketamine, and etomidate on active tension were 1.56 × 10?5 M, 4.97 × 10?5 M, 3.52 × 10?4 M, and 2.73 × 10?5 M, respectively.
Conclusions: All four intravenous hypnotics relaxed the uterine smooth muscle of rats except for ketamine in low concentrations (10?7 to 10?5 M). Propofol had the greatest relaxant effects on isolated rat uterine smooth muscle among these hypnotics. It seems that ketamine is a suitable obstetric hypnotic agent for hypovolemic parturients and propofol is a useful hypnotic agent for uterine relaxation during pregnancy.
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KEYWORD
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etomidate, hypnotics, ketamine, propofol, rat uterine smooth muscle, thiopental
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